Folate and Methylation Status in Relation to Phosphorylated Tau Protein(181P) and β-Amyloid(1–42) in Cerebrospinal Fluid

R Obeid, M Kasoha, JP Knapp, P Kostopoulos… - Clinical …, 2007 - academic.oup.com
Background: Increased plasma total homocysteine (tHcy) is a risk factor for neurological
diseases, but the underlying pathophysiology has not been adequately explained. Methods …

Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease

J Popp, P Lewczuk, M Linnebank… - Journal of …, 2009 - content.iospress.com
Disturbed homocysteine metabolism is a risk factor for Alzheimer's disease (AD) and may
contribute to the disease pathophysiology by increasing both amyloid-β (Aβ) production and …

Elevated plasma homocysteine level is not primarily related to Alzheimer's disease

K Nilsson, L Gustafson, B Hultberg - Dementia and geriatric cognitive …, 2012 - karger.com
Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a
potential risk factor for Alzheimer's disease (AD). Methods: We have investigated the main …

Folate and homocysteine in the cerebrospinal fluid of patients with Alzheimer's disease or dementia: a case control study

MA Smach, N Jacob, JL Golmard, B Charfeddine… - European …, 2011 - karger.com
Background: Amyloid deposition in the brain is an early event in Alzheimer's disease (AD),
but a dysfunction of the blood-brain barrier or a disturbance in the metabolism of folate and …

Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease

MC Irizarry, ME Gurol, S Raju, R Diaz-Arrastia… - Neurology, 2005 - AAN Enterprises
Background: Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular
disease and is reported to be an independent risk factor for Alzheimer disease (AD) and …

Methylation status and neurodegenerative markers in Parkinson disease

R Obeid, A Schadt, U Dillmann, P Kostopoulos… - Clinical …, 2009 - academic.oup.com
Background: Increased concentrations of plasma total homocysteine (tHcy) have been
associated with age-related diseases, including dementia, stroke, and Parkinson disease …

Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer's Disease: A Case-Control Study

F Ma, T Wu, J Zhao, L Ji, A Song, M Zhang, G Huang - Nutrients, 2017 - mdpi.com
Homocysteine (Hcy) is a risk factor for brain atrophy, cognitive impairment, and dementia.
Vitamin B12 and folate are cofactors necessary for the methylation of Hcy. However, there is …

[HTML][HTML] Homocysteine and folate as risk factors for dementia and Alzheimer disease

G Ravaglia, P Forti, F Maioli, M Martelli… - The American journal of …, 2005 - Elsevier
Background: In cross-sectional studies, elevated plasma total homocysteine (tHcy)
concentrations have been associated with cognitive impairment and dementia. Incidence …

Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel

EH Mizrahi, A Bowirrat, DW Jacobsen… - Journal of the …, 2004 - Elsevier
High plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and stroke and
Alzheimer's disease (AD). An inverse relationship has been reported between tHcy and …

Plasma homocysteine concentration relates to the severity but not to the duration of Alzheimer's disease

K Nilsson, L Gustafson… - International journal of …, 2004 - Wiley Online Library
Background It has been reported that plasma tHcy concentration is elevated in patients with
Alzheimer's disease (AD) and relates to the progress or the development of AD. In the …