We examined the effects of quinidine (5-20 microM) on transmembrane action potentials
and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine …

Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

In guinea pig cardiac myocytes quinidine (20 microM) caused less than 10% tonic block
reduction of the sodium current at-120 mV, but a fast pulse train reduced it more than 90 …

ABSTRACT Nawrath, Hermann: Action potential, membrane currents and force of
contraction in mammalian heart muscle fibers treated with quinidine. J. Pharmacol. Exp …

1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

Although metabolites of quinidine are active in animal models and can accumulate to
plasma levels similar to those of quinidine during chronic therapy, their effects on cardiac …

The effects of N-acetylprocainamide (NAPA) and sotalol on membrane current systems of
guinea-pig ventricular myocytes were examined and compared with those of quinidine using …

Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac
rhythm disturbances. It depresses the rapid initial depolarization of the action potential by …

We used standard microelectrode techniques to evaluate the effects of lidocaine and
quinidine on canine Purkinje fibers at normal pH (7.3) and in the presence of acidosis (pH …