Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed medications for relief
of pain and inflammation. Recent animal studies using models of fracture healing and bone …

Nonsteroidal anti‐inflammatory drug (NSAID) use continues to expand at a remarkable rate
due both to the broad spectrum of clinical applications for these medications and to the …

The use of the new selective cyclooxygenase-2 (COX-2) inhibitors (such as celecoxib and
rofecoxib) for the treatment of pain and inflammation caused by fractures, cementless total …

These animal data, together with the view of limited scientifically robust clinical evidence in
humans, indicate that physicians consider only short-term administration of COX-2 inhibitors …

Nonspecific and COX-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) function by
inhibiting the cyclooxygenase isoenzymes and effectively reduce pain and inflammation …

Traditional non‐steroidal anti‐inflammatory drugs (NSAID) and selective cyclooxygenase‐2
(COX‐2) inhibitors are widely used in the treatment of pain, including bone fracture pain and …

In these two papers, the authors tried to answer questions relating to the effect of NSAIDs on
bone healing after posttraumatic fractures and aseptic loosening of arthroplasties. While we …

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs
worldwide. They are prescribed for orthopaedic conditions such as osteoarthritis, soft-tissue …

Prostaglandins generated by cyclo-oxygenase-2 (COX-2) clearly play a role in both the
formation and resorption of bone. Such effects on bone formation enable the use of …

Since their approval by the FDA and introduction in 1999, COX-2 inhibitors have rapidly
become the 11th-largest therapeutic class of drugs in the US In 2000, Celebrex (celecoxib) …