Therapeutic proteins can be challenging to develop due to their complexity and the
requirement of an acceptable formulation to ensure patient safety and efficacy. To date …

Therapeutic protein candidates should exhibit favorable properties that render them suitable
to become drugs. Nevertheless, there are no well-established guidelines for the efficient …

Over the past few years, emphasis in drug development has shifted substantially from small
organic compounds toward macromolecules, particularly monoclonal antibodies (mAbs), to …

Stabilization and formulation of therapeutic proteins against physical instability, both
structural alterations and aggregation, is particularly challenging not only due to each …

In this study, an automated high-throughput relative chemical stability (RCS) assay was
developed in which various therapeutic proteins were assessed to determine stability based …

Still today, high-concentration protein formulations are often developed based on high-
throughput experimental screening approaches. Although likely delivering working …

Biologics continue to play an increasingly dominant role in the modern pharmaceutical
market. The primary objective of formulation development is to efficiently deliver a …

Purpose This study aimed to introduce a quick method for developing formulations during
the early stages of biopharmaceutical drug development, starting from the isoelectric point (p …

Peptide and protein design for biopharmaceutical and food applications gained
considerable attention in recent years. Numerous peptides and proteins are approved every …

Protein therapeutics have steadily gained importance for the targeted pharmacotherapy of
severe diseases in the last decades. The specific targeting of a single antigen has proven to …