Retrospective studies have suggested that combination antibiotic therapy for severe
bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a …

Background Although monotherapy for pneumococcal pneumonia is standard, a survival
benefit of combination β-lactam and macrolide therapy has been suggested. Hypothesis …

Prospective observational study of bacteremic pneumococcal p... : Critical Care Medicine
Prospective observational study of bacteremic pneumococcal pneumonia: Effect of discordant …

BACKGROUND: Approximately 10% of patients hospitalized with community‐acquired
pneumonia (CAP) are bacteremic. Bacteremic Streptococcus pneumoniae pneumonia …

To assess the association between inclusion of a macrolide in a β-lactam—based empirical
antibiotic regimen and mortality among patients with bacteremic pneumococcal pneumonia …

Inadequate antibiotic therapy, generally defined as microbiologically ineffective anti-infective
therapy against the causative pathogen, can influence patient outcome. However, the …

We performed a prospective, international, observational study of 844 hospitalized patients
with blood cultures positive for Streptococcus pneumoniae. Fifteen percent of isolates had in …

Objective: To assess whether combination antibiotic therapy improves outcome of severe
community-acquired pneumonia in the subset of patients with shock. Design: Secondary …

To determine the impact of initial antimicrobial choice on 30-day mortality rate in patients
with community-acquired pneumonia due to Streptococcus pneumoniae (CAP-SP), a …

Limited data are available about the impact of antimicrobial resistance on clinical outcomes
in cases of pneumococcal pneumonia. This was studied in 146 persons hospitalized with …