Regulatory T (Treg) cells constitute a unique T-cell lineage that plays a pivotal role in the
maintenance of the peripheral tolerance. The transcription factor Foxp3 (Forkhead box P3) …

Regulatory T (TReg) cells constitute a unique T-cell lineage that has a crucial role in
immunological tolerance. Several years ago, forkhead box P3 (FOXP3) was identified as the …

Regulatory T cells (Treg cells) have been well documented to have a crucial physiological
role in preventing the development of autoimmune diseases and keeping self‐tolerance …

Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is,
understandably, a highly controlled process and one which many investigators want to …

FOXP3 is playing an essential role for T regulatory cells and is involved in the molecular
mechanisms controlling immune tolerance. Although the biological relevance of this …

Regulatory T cells (Tregs) are now among the most intensively studied of T cell subsets and
among the major targets of immune drug development because of their fundamental role in …

Regulatory T (Treg) cells are critical for tolerance to self-antigens and for preventing
autoimmunity. Foxp3 has been identified as a Treg cell lineage-defining transcription factor …

Regulatory T cells (Tregs) act in trans to control immune responses. The suppressive
function of Tregs relies heavily on high and stable expression of the transcription factor …

Background The forkhead box transcription factor, Foxp3, is master regulator of the
development and function of CD4+ CD25+ T regulatory (Treg) cells that limit autoimmunity …

In the periphery, tolerance to self antigens is mainly mediated by the CD4+ CD25+ FOXP3+
subset of regulatory T cells, which can suppress the activity of autoreactive T cells that have …