Emergence of reproducible spatiotemporal activity during motor learning

AJ Peters, SX Chen, T Komiyama - Nature, 2014 - nature.com
The motor cortex is capable of reliably driving complex movements, yet exhibits
considerable plasticity during motor learning,,,,,,,. These observations suggest that the …

Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task

M Laubach, J Wessberg, MAL Nicolelis - Nature, 2000 - nature.com
When an animal learns to make movements in response to different stimuli, changes in
activity in the motor cortex seem to accompany and underlie this learning,,,,,. The precise …

Rapid formation and selective stabilization of synapses for enduring motor memories

T Xu, X Yu, AJ Perlik, WF Tobin, JA Zweig, K Tennant… - Nature, 2009 - nature.com
Novel motor skills are learned through repetitive practice and, once acquired, persist long
after training stops,. Earlier studies have shown that such learning induces an increase in …

Cortical preparatory activity indexes learned motor memories

X Sun, DJ O'Shea, MD Golub, EM Trautmann, S Vyas… - Nature, 2022 - nature.com
The brain's remarkable ability to learn and execute various motor behaviours harnesses the
capacity of neural populations to generate a variety of activity patterns. Here we explore …

Consolidation in human motor memory

T Brashers-Krug, R Shadmehr, E Bizzi - Nature, 1996 - nature.com
LEARNING a motor skill sets in motion neural processes that continue to evolve after
practice has ended, a phenomenon known as consolidation1–4. Here we present …

Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo

M Fu, X Yu, J Lu, Y Zuo - Nature, 2012 - nature.com
Many lines of evidence suggest that memory in the mammalian brain is stored with distinct
spatiotemporal patterns,. Despite recent progresses in identifying neuronal populations …

Reorganization of corticospinal output during motor learning

AJ Peters, J Lee, NG Hedrick, K O'Neil… - Nature …, 2017 - nature.com
Motor learning is accompanied by widespread changes within the motor cortex, but it is
unknown whether these changes are ultimately funneled through a stable corticospinal …

Distinct descending motor cortex pathways and their roles in movement

MN Economo, S Viswanathan, B Tasic, E Bas… - Nature, 2018 - nature.com
Activity in the motor cortex predicts movements, seconds before they are initiated. This
preparatory activity has been observed across cortical layers, including in descending …

Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice

T Komiyama, TR Sato, DH O'Connor, YX Zhang… - Nature, 2010 - nature.com
Cortical neurons form specific circuits, but the functional structure of this microarchitecture
and its relation to behaviour are poorly understood. Two-photon calcium imaging can …

A motor cortex circuit for motor planning and movement

N Li, TW Chen, ZV Guo, CR Gerfen, K Svoboda - Nature, 2015 - nature.com
Activity in motor cortex predicts specific movements seconds before they occur, but how this
preparatory activity relates to upcoming movements is obscure. We dissected the conversion …