Revised Manuscript Received August 14, 1995® abstract: A series of 5-substituted 2-
aminopyrrolo [2, 3-< i] pyrimidin-4 (3//)-ones have been synthesized in order to study the …

The enzyme tRNA− guanine transglycosylase (TGT, EC 2.4. 2.29) catalyzes a
posttranscriptional transglycosylation reaction involved in the incorporation of the modified …

tRNA–guanine transglycosylase (TGT) is a key enzyme in the post-transcriptional
modification of certain tRNAs with the pyrrolopyrimidine base queuine. TGT is required for …

Abstract tRNA-guanine transglycosylase (TGT) is the enzyme responsible for the post-
transcriptional modification of specific tRNAs (Asn, Asp, His and Tyr) with queuine. In E. coli …

Revised Manuscript Received February 25, 1993 abstract: tRNA-guanine transglycosylase
(TGT) is the enzyme responsible for the post-transcriptional modification of specific tRNAs …

The modified RNA base queuine [7-(4, 5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-
deazaguanine] is present in tRNA because of a unique base-exchange process catalyzed …

Mechanism-Based Inactivation of tRNA-Guanine Transglycosylase from Escherichia coli by
2-Amino-5-(fluoromethyl)pyrrolo[2,3-d]pyr Page 1 Biochemistry 1995, 34, 15539—15544 …

Procaryotic tRNA-guanine transglycosylase (TGT) catalyzes the posttranscriptional base
exchange of the queuine precursor 7-aminomethyl-7-deazaguanine (preQ1) with the …

tRNA-guanine transglycosylase (TGT) catalyzes the exchange of queuine (or a precursor)
for guanine 34 in tRNA. The minimal RNA recognition motif for TGT has been found to …

In order to probe the interaction between tRNA and the tRNA hypermodifying enzyme, tRNA-
guanine transglycosylase (TGT) from Escherichia coli, we have undertaken the generation …