Summary Type‐I interferons (IFN‐I) are used as common antiviral drugs for a range of viral
diseases in clinic. However, the antiviral efficacy of IFN‐I is largely restricted by negative …

Type I interferons are broadly used for antiviral therapy in clinical. However, the IFNs-
mediated antiviral efficacy is commonly restricted by negative regulators. Here, we show that …

STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation
is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1) …

Deubiquitinating enzymes (DUBs) are cysteine proteases that reverse the ubiquitination by
removing ubiquitins from the target protein. The human genome encodes∼ 100 potential …

Ubiquitination and deubiquitination have emerged as critical regulatory processes in the
virus-triggered type I interferon (IFN) induction pathway. In this study, we carried out a …

Type I interferons (IFNs), as major components of the innate immune system, play a vital role
in host resistance to a variety of pathogens. Canonical signaling mediated by type I IFNs …

Abstract Ubiquitin-specific protease 18 (USP18) as a negative regulator of the Jak/STAT
signaling pathway plays an important role in the host innate immune response. USP18 has …

Abstract Type-I interferons (IFN-I) are important antiviral drugs which are widely used in
clinical therapy of diverse viral infections. However, understanding the detailed mechanisms …

Abstract Type I interferon (IFN-I) exhibits broad-spectrum antiviral properties and is
commonly employed in clinical for the treatment of viral infections. In this study, we unveil …

Viral infection triggers a series of signaling cascades, which converge to activate the
transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3) …