Genomic features of rapid versus late relapse in triple negative breast cancer

Y Zhang, S Asad, Z Weber, D Tallman, W Nock… - BMC cancer, 2021 - Springer
Background Triple-negative breast cancer (TNBC) is a heterogeneous disease and we have
previously shown that rapid relapse of TNBC is associated with distinct sociodemographic …

Characteristics of recurrence, predictors for relapse and prognosis of rapid relapse triple-negative breast cancer

SL Cai, JJ Liu, YX Liu, SH Yu, X Liu, XQ Lin… - Frontiers in …, 2023 - frontiersin.org
Background Triple-negative breast cancer (TNBC) patients who recur at different times are
associated with distinct biological characteristics and prognoses. Research on rapid-relapse …

Sociodemographic factors associated with rapid relapse in triple-negative breast cancer: a multi-institution study

S Asad, CH Barcenas, RJ Bleicher, AL Cohen… - Journal of the National …, 2021 - jnccn.org
Background: Triple-negative breast cancer (TNBC) accounts for disproportionately poor
outcomes in breast cancer, driven by a subset of rapid-relapse TNBC (rrTNBC) with marked …

The early-stage triple-negative breast cancer landscape derives a novel prognostic signature and therapeutic target

YS Yang, YX Ren, CL Liu, S Hao, XE Xu, X Jin… - Breast Cancer Research …, 2022 - Springer
Purpose Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. Patients
with early-stage TNBCs have distinct likelihood of distant recurrence. This study aimed to …

Whole-exome sequencing reveals high mutational concordance between primary and matched recurrent triple-negative breast cancers

J Kaur, DS Chandrashekar, Z Varga, B Sobottka… - Genes, 2023 - mdpi.com
Purpose: Triple-negative breast cancer (TNBC) is a molecularly complex and
heterogeneous breast cancer subtype with distinct biological features and clinical behavior …

Comprehensive profiling of poor-risk paired primary and recurrent triple-negative breast cancers reveals immune phenotype shifts

KE Hutchinson, SE Yost, CW Chang, RM Johnson… - Clinical Cancer …, 2020 - AACR
Purpose: Emerging data suggest immune checkpoint inhibitors have reduced efficacy in
heavily pretreated triple-negative breast cancers (TNBC), but underlying mechanisms are …

The association between early-onset diagnosis and clinical outcomes in triple-negative breast cancer: a systematic review and meta-analysis

RB Basmadjian, K Chow, D Kim, M Kenney… - Cancers, 2023 - mdpi.com
Simple Summary Epidemiologic studies have observed higher risks of breast cancer
recurrence and death in women diagnosed< 40 years of age compared to≥ 40 years. There …

Identification of immunosuppressive signature subtypes and prognostic risk signatures in triple-negative breast cancer

R Ding, Y Wang, J Fan, Z Tian, S Wang, X Qin… - Frontiers in …, 2023 - frontiersin.org
Purpose Immune checkpoint blockade (ICB) therapy has transformed the treatment of triple-
negative breast cancer (TNBC) in recent years. However, some TNBC patients with high …

[HTML][HTML] Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options

JY So, J Ohm, S Lipkowitz, L Yang - Pharmacology & therapeutics, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor …

Clinical genomic profiling to identify actionable alterations for very early relapsed triple-negative breast cancer patients in the Chinese population

L Wang, Q Zhai, Q Lu, K Lee, Q Zheng, R Hong… - Annals of …, 2021 - Taylor & Francis
Background Triple-negative breast cancer (TNBC) represents about 19% of all breast
cancer cases in the Chinese population. Lack of targeted therapy contributes to the poorer …