Mitochondria buffer Ca2+ entry but not intracellular Ca2+ release in mouse DRG neurones

N Svichar, P Kostyuk, A Verkhratsky - Neuroreport, 1997 - journals.lww.com
MITOCHONDRIAL Ca 2+ pool was investigated in dorsal root ganglion neurones acutely
isolated from 4–5 week old mice. Under the resting conditions application of mitochondrial …

Mitochondrial participation in the modulation of calcium transients in DRG neurons

N Svichar, V Shishkin, P Kostyuk - Neuroreport, 1999 - journals.lww.com
THE effects of the mitochondrial Na+/Ca 2+ exchange blocker tetraphenylphosphonium
(TPP+) and the permeability transition blocker cyclosporinA (CysA) on the ability of …

Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons

JL Werth, SA Thayer - Journal of Neuroscience, 1994 - Soc Neuroscience
We sought to determine whether low-affinity, high-capacity mitochondrial Ca2+ uptake
contributes to buffering physiological Ca2+ loads in sensory neurons. Intracellular free …

Role of mitochondria in intracellular calcium signaling in primary and secondary sensory neurones of rats

V Shishkin, E Potapenko, E Kostyuk, O Girnyk… - Cell Calcium, 2002 - Elsevier
The participation of different calcium-regulated mechanisms in the generation of cytosolic
Ca2+ transients during neuronal excitation has been compared in isolated large and small …

Ca2+- and Metabolism-Related Changes of Mitochondrial Potential in Voltage-Clamped CA1 Pyramidal Neurons In Situ

S Schuchmann, M Luckermann… - Journal of …, 2000 - journals.physiology.org
In hippocampal slices from rats, dialysis with rhodamine-123 (Rh-123) and/or fura-2 via the
patch electrode allowed monitoring of mitochondrial potential (ΔΨ) changes and …

A Reevaluation of the Role of Mitochondria in Neuronal Ca2+ Homeostasis

SL Budd, DG Nicholls - Journal of neurochemistry, 1996 - Wiley Online Library
The ability of mitochondrial Ca2+ transport to limit the elevation in free cytoplasmic Ca2+
concentration in neurones following an imposed Ca2+ load is reexamined. Cultured …

Blockade of mitochondrial Ca2+ uptake by mitochondrial inhibitors amplifies the glutamate‐induced calcium response in cultured cerebellar granule cells

B Khodorov, V Pinelis, T Storozhevykh… - FEBS …, 1999 - Wiley Online Library
The objective of this study was to evaluate the role of mitochondrial Ca2+ uptake (MCU) in
modulation (shaping) of the glutamate (Glu)‐induced changes in neuronal cytoplasmic …

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

MR Duchen - Biochemical Journal, 1992 - portlandpress.com
Depolarization of neurons promotes Ca2+ influx through voltage-activated channels, raising
the intracellular Ca2+ concentration ([Ca2+] i). The consequences of such changes in …

Mitochondrial calcium waves by electrical stimulation in cultured hippocampal neurons

Y Eom, SR Kim, YK Kim, SH Lee - Molecular Neurobiology, 2024 - Springer
Mitochondria are critical to cellular Ca2+ homeostasis via the sequestering of cytosolic Ca2+
in the mitochondrial matrix. Mitochondrial Ca2+ buffering regulates neuronal activity and …

Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytes

RC Reyes, V Parpura - Journal of Neuroscience, 2008 - Soc Neuroscience
Vesicular glutamate release from astrocytes depends on mobilization of free Ca 2+ from the
endoplasmic reticulum (ER), and extracellular space to elevate cytosolic Ca 2+(Ca 2+ cyt) …