Previously we reported that the cuff model of peripheral neuropathy, in which a 2 mm
polyethylene tube is implanted around the sciatic nerve, exhibits aspects of neuropathic pain …

Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key
mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We …

Various hypotheses have been proposed to account for the mechanical hyperalgesia and
spontaneous pain seen in animal models of peripheral neuropathy. The purpose of the …

Under intact and spinalized conditions, we compared the responses of deep spinal dorsal
horn (DH) nociceptive-specific (NS) and wide-dynamic range (WDR) neurons to …

The mechanisms underlying the relief of neuropathic pain of peripheral origin by spinal cord
stimulation (SCS) are poorly understood. The present study was designed to investigate the …

Background Spinal cord stimulation (SCS) and peripheral nerve stimulation (PNS) are
thought to reduce pain by activating a sufficient number of large myelinated (A β) fibres …

Non‐technical summary The dorsal horn of the spinal cord is the first site in the central
nervous system where painful sensory information is processed before transmission to the …

Background: The sites of action and cellular mechanisms by which spinal cord stimulation
reduces neuropathic pain remain unclear. Methods: We examined the effect of bipolar …

The effect of Spinal Cord Stimulation (SCS) in chronic neuropathic pain is inversely related
to the severity of mechanical allodynia and the underlying mechanisms are poorly …

Admiral Lord Nelson lost his right arm in a sea battle some years before his successful
encounter with the forces of Napoleon at the Battle of Trafalgar (1805). Like virtually all …