Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Y Bei, T Xu, D Lv, P Yu, J Xu, L Che, A Das… - Basic research in …, 2017 - Springer
Extracellular vesicles (EVs) serve an important function as mediators of intercellular
communication. Exercise is protective for the heart, although the signaling mechanisms that …

Extracellular vesicles and cardiovascular system: Biomarkers and Cardioprotective Effectors

S Femminò, C Penna, S Margarita, S Comità… - Vascular …, 2020 - Elsevier
In the last few decades extracellular vesicles (EVs), which include exosomes and
microvesicles, have attracted significant interest in cardiovascular pathophysiology due to …

[HTML][HTML] Plasma-derived extracellular vesicles released after endurance exercise exert cardioprotective activity through the activation of antioxidant pathways

V Lisi, G Senesi, N Bertola, M Pecoraro, S Bolis… - Redox Biology, 2023 - Elsevier
Cardiovascular diseases (CVD) can cause various conditions, including an increase in
reactive oxygen species (ROS) levels that can decrease nitric oxide (NO) availability and …

Myocardial ischemia‐reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury

X Ge, Q Meng, L Wei, J Liu, M Li… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) curb important biological functions. We previously disclosed that
ischemia‐reperfusion (IR) induces increased release of EVs (IR‐EVs) in the heart. However …

Cardioprotective role of extracellular vesicles: a highlight on exosome beneficial effects in cardiovascular diseases

J Rezaie, R Rahbarghazi, M Pezeshki… - Journal of cellular …, 2019 - Wiley Online Library
Extracellular vesicles (EVs) are nano‐sized vesicles, released from many cell types
including cardiac cells, have recently emerged as intercellular communication tools in cell …

Intra-cardiac release of extracellular vesicles shapes inflammation following myocardial infarction

X Loyer, I Zlatanova, C Devue, M Yin… - Circulation …, 2018 - Am Heart Assoc
Rationale: A rapid and massive influx of inflammatory cells occurs into ischemic area after
myocardial infarction (MI), resulting in local release of cytokines and growth factors. Yet, the …

Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release

A Anselmo, D Frank, L Papa… - European heart …, 2021 - academic.oup.com
Aims Increased shedding of extracellular vesicles (EVs)—small, lipid bilayer-delimited
particles with a role in paracrine signalling—has been associated with human pathologies …

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip

M Yadid, JU Lind, HAM Ardoña, SP Sheehy… - Science translational …, 2020 - science.org
Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective
effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the …

Physical exercise induces rapid release of small extracellular vesicles into the circulation

C Frühbeis, S Helmig, S Tug, P Simon… - Journal of …, 2015 - Taylor & Francis
Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the
purpose of cell communication and tissue homeostasis. EVs are present in all body fluids …

Circulating cardiomyocyte-derived extracellular vesicles reflect cardiac injury during systemic inflammatory response syndrome in mice

H Hegyesi, É Pallinger, S Mecsei, B Hornyák… - Cellular and Molecular …, 2022 - Springer
The release of extracellular vesicles (EVs) is increased under cellular stress and
cardiomyocyte damaging conditions. However, whether the cardiomyocyte-derived EVs …