The flavonoid quercetin inhibits dimethylnitrosamine‐induced liver damage in rats

ES Lee, HE Lee, JY Shin, S Yoon… - Journal of pharmacy …, 2003 - Wiley Online Library
Quercetin, one of the most abundant flavonoids in human diet has been reported to exhibit a
wide range of pharmacological properties. In this study, we investigated the protective effect …

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

Y Wan, MH Tang, XC Chen, LJ Chen… - Brazilian Journal of …, 2014 - SciELO Brasil
Immune response plays an important role in the development of hepatic fibrosis. In the
present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis …

Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

AD Mariee, GM Abd-Allah… - Pharmaceutical …, 2012 - Taylor & Francis
Context: Quercetin, a dietary-derived flavonoid, is ubiquitous in fruits and vegetables and
plays important roles in human health by virtue of its antioxidant activity. Objective: This …

Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling

R Wang, H Zhang, Y Wang, F Song, Y Yuan - International …, 2017 - Elsevier
Quercetin, a natural flavonoid, has been used as a nutritional supplement for its anti-
inflammatory and antioxidative properties. Quercetin was reported to exhibit a wide range of …

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance

LD Hernández‐Ortega… - Journal of …, 2012 - Wiley Online Library
Abstract Background and Aim Development of hepatic cirrhosis involves oxidative stress,
inflammation, hepatic stellate cells (HSC) s activation and fibrosis. On the other hand …

The proanthocyanidins inhibit dimethylnitrosamine-induced liver damage in rats

MO Shin, S Yoon, JO Moon - Archives of pharmacal research, 2010 - Springer
Proanthocyanidins are naturally occurring compounds widely available in fruits, vegetables,
nuts and seeds. They are a class of phenolic compounds and have been reported to exhibit …

Beneficial effect of quercetin on cholestatic liver injury

SY Lin, YY Wang, WY Chen, YH Chuang… - The Journal of …, 2014 - Elsevier
Bile duct obstruction and subsequent cholestasis are associated with hepatocellular injury,
cholangiocyte proliferation, stellate cell activation, Kupffer cell activation, oxidative stress …

Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

L Wu, Q Zhang, W Mo, J Feng, S Li, J Li, T Liu, S Xu… - Scientific reports, 2017 - nature.com
The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a
characteristic response to acute or chronic liver injury. Mice were randomized to bile duct …

Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways

X Li, Q Jin, Q Yao, B Xu, Z Li, C Tu - Toxicology letters, 2016 - Elsevier
This study aimed to investigate the effects of quercetin on liver fibrogenesis in mice and to
elucidate the underlying molecular mechanisms. Mice were administered with carbon …

[PDF][PDF] Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin

JF Su, CJ Guo, JY Wei, JJ Yang, YG Jiang… - Biomedical and …, 2003 - besjournal.com
Objective To investigate the possible protection provided by oral quercetin pretreatment
against hepatic ischemia-reperfusion injury in rats. Methods The quercetin (0.13 mmol/kg) …