M Castanheira, AP Davis, AW Serio, KM Krause… - … and Infectious Disease, 2019 - Elsevier
Aminoglycoside-nonsusceptible isolates of Escherichia coli, Klebsiella, Proteus, and Enterobacter species (480/3675) from US hospitals collected during 2014–2015 were …
Methods. A total of 10,451 Enterobacteriaceae (ENT) consecutively collected from 84 United States (US) medical centers and 250 carbapenem-resistant ENT (CRE) collected from 38 …
ABSTRACT Plazomicin was active against 97.0% of 8,783 Enterobacterales isolates collected in the United States (2016 and 2017), and only 6 isolates carried 16S rRNA …
Background Plazomicin is a next-generation aminoglycoside that was developed to overcome common aminoglycoside-resistance mechanisms. Objectives We evaluated the …
HS Sader, RE Mendes, JH Kimbrough… - Open Forum …, 2023 - academic.oup.com
Abstract Background The Clinical and Laboratory Standards Institute (CLSI) lowered the Enterobacterales-susceptible/-resistant breakpoints for amikacin in 2023 from≤ 16/≥ 64 …
Plazomicin and comparator agents were tested by using the CLSI reference broth microdilution method against 4,825 clinical isolates collected during 2014 and 2015 in 70 …
WA Fleischmann… - Antimicrobial agents …, 2020 - Am Soc Microbiol
The worldwide spread of multidrug-resistant Enterobacterales is a serious threat to public health. Here, we compared the MICs of plazomicin, amikacin, gentamicin, and tobramycin …
MC López-Diaz, E Culebras… - Antimicrobial agents …, 2017 - Am Soc Microbiol
The activity of plazomicin and clinically relevant aminoglycosides was tested against 346 extended-spectrum-β-lactamase/AmpC-producing Escherichia coli urinary isolates, and the …
A Walkty, H Adam, M Baxter, A Denisuik… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Plazomicin is a next-generation aminoglycoside that is not affected by most clinically relevant aminoglycoside-modifying enzymes. The in vitro activities of plazomicin and …