Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

The basic unit of chromatin, the nucleosome core particle (NCP), controls how DNA in
eukaryotic cells is compacted, replicated and read. Since its discovery, biochemists have …

Highlights•Cryo-electro microscopy reveals the native conformation of chromatin fiber both
in vitro and in situ.•Presence of linker histone and ionic conditions determines the level of …

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

Chromosomes condense during mitosis in most eukaryotes. This transformation involves
rearrangements at the nucleosome level and has consequences for transcription. Here, we …

Nucleosomes, the basic unit of chromatin, are repetitively spaced along DNA and regulate
genome expression and maintenance. The long linear chromatin molecule is extensively …

A long strand of DNA is wrapped around the core histone and forms a nucleosome.
Although the nucleosome has long been assumed to be folded into 30-nm chromatin fibres …

In Eukaryotes, DNA is wound around the histone octamer forming the basic chromatin unit,
the nucleosome. Atomic structures have been obtained from crystallography and single …

The 30-nm fiber is commonly formed by oligonucleosome arrays in vitro but rarely found
inside cells. To determine how chromatin higher-order structure is controlled, we used …

The organization and dynamics of chromatin fiber play crucial roles in regulating DNA
accessibility for gene expression. Here we combine cryoelectron tomography (cryo-ET), sub …