Background At present there is no effective and accepted therapy for hepatic fibrosis.
Transforming growth factor (TGF)-β1 signaling pathway contributes greatly to hepatic …

The aim of the study was to investigate the effect of curcumin on the liver fibrosis induced by
carbon tetrachloride (CCl4) in rats, and to elucidate its underlying molecular mechanisms …

This study aimed to investigate the protective effect of curcumin against carbon tetrachloride
(CCl4)-induced acute liver injury in a mouse model, and to explain the underlying …

Abstract Introduction and Objectives Curcumin, a polyphenol, is a natural compound that
has been widely studied as a hepatoprotector; however, only a few studies have examined …

The hepatoprotective effects of curcumin against alcohol-induced hepatic fibrosis have
rarely been discussed and its mechanisms of action in alcohol-induced liver disease remain …

This study was designed to investigate the prophylactic effects and the mechanisms of
curcumin on liver fibrosis in rats. Liver fibrosis was induced in 72 Sprague Dawley rats by …

Inflammation and hepatic stellate cell (HSC) activation are the most crucial steps in the
formation of hepatic fibrosis. Hepatocytes damaged by viral or bacterial infection, alcohol or …

Curcumin and saikosaponin A as antioxidants improve antioxidant status. This study
investigated the anti-inflammatory and antifibrotic actions of curcumin and saikosaponin A …

Epithelial-mesenchymal transition (EMT) occurs during adult tissue remodeling responses
including carcinogenesis and fibrosis. Existing evidence reveals that hepatocytes can …

Curcumin is a phytophenolic compound, which is highly efficacious for treating several
inflammatory diseases. The aim of this study was to evaluate the efficacy of curcumin in …