▪ Abstract DNA topoisomerases solve the topological problems associated with DNA
replication, transcription, recombination, and chromatin remodeling by introducing …

▪ Abstract Topoisomerases are enzymes that use DNA strand scission, manipulation, and
rejoining activities to directly modulate DNA topology. These actions provide a powerful …

Recent structural and mechanistic studies, as well as the discovery of new enzymes in the
DNA topoisomerase family, allow these enzymes to be classified into three groups. Each …

DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …

The various problems of disentangling DNA strands or duplexes in a cell are all rooted in the
double-helical structure of DNA. Three distinct subfamilies of enzymes, known as the DNA …

Topoisomerases are ubiquitous proteins found in all three domains of life. They change the
topology of DNA via transient breaks on either one or two of the DNA strands to allow …

INTRODUCTION The faithful replication and segregation of chromosomes as part of the cell
division cycle requires that topological changes be imposed upon cellular DNA …

Publisher Summary Topoisomerases are a diverse and important group of enzymes.
Although attention has until recently been focused on their ability to interconvert DNA …

DNA topoisomerases are ubiquitous enzymes that control the level of supercoiling of DNA in
cells. There are several classes, each with distinct properties, which are briefly discussed in …

Although the genetic code is defined by a linear array of nucleotides, it is the three‐
dimensional structure of the double helix that regulates most of its cellular functions. Over …