Mitochondrial volume homeostasis is a housekeeping cellular function, thought to help
regulate oxidative capacity, apoptosis, and mechanical signaling. The volume is mainly …

Mitochondria are the primary generators of ATP and are important regulators of intracellular
calcium homeostasis. These organelles are dynamically transported along lengthy neuronal …

In this study we measured ΔΨm in single isolated brain mitochondria using rhodamine 123.
Mitochondria were attached to coverslips and superfused with K+-based HEPES-buffer …

Cells precisely regulate mitochondrial movement in order to balance energy needs and
avoid cell death. Neurons are particularly susceptible to disturbance of mitochondrial motility …

In this chapter we describe the fundamental mechanisms by which mammalian cells
regulate energy production, and we put emphasis on the importance of mitochondrial …

Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

Mitochondrial dysfunction is central to the pathogenesis of neurological disorders. Neurons
rely on oxidative phosphorylation to meet their energy requirements and thus alterations in …

Mitochondria are intracellular organelles in which high energy phosphate is produced.
Ischemia causes depletion of the materials necessary to produce this phosphate and …

A controlled regulation of mitochondrial mass through either the production (biogenesis) or
the degradation (mitochondrial quality control) of the organelle represents a crucial step for …

Alterations in mitochondrial function may have a central role in the pathogenesis of many
neurodegenerative diseases. The study of mitochondrial dysfunction has typically focused …