Nelfinavir (Viracept®) is a potent, non-peptidic inhibitor of HIV-1 Protease, which has been marketed for the treatment of HIV infected patients. However, HIV-1 develops drug …
M Yoosefian, MZ Moghani, A Juan - Computers in Biology and Medicine, 2022 - Elsevier
Starting three decades ago and spreading rapidly around the world, acquired immunodeficiency syndrome (AIDS) is an infectious disease distinct from other contagious …
M Beihaghi, H Tehrani, N Akbari… - … in Biotechnology and …, 2022 - rbes.rovedar.com
Introduction: This research was conducted to investigate the molecular interaction of HIV protease inhibitor drugs using molecular docking. HIV protease is responsible for …
We have investigated and highlighted the behavior of binding residue, Asp25 by computational analysis, which play an important role in understanding docking process with …
The intense research on small molecule inhibitors of Human immunodeficiency virus (HIV)- protease (PR) has produced a diverse class of chemical scaffolds which includes clinically …
Human immunodeficiency virus infection/acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication …
GD Hu, T Zhu, SL Zhang, D Wang, QG Zhang - European journal of …, 2010 - Elsevier
The single mutations I50V, V82A and I84V are considered as the key residue mutations of the HIV-1 protease drug resistance. The rank of calculated absolute binding free energies …
S Alcaro, A Artese… - Journal of chemical …, 2009 - ACS Publications
The current strategy to improve the quality of life of Human Immunodeficiency Virus (HIV) infected individuals through suppressing viral replication and maintaining the virus at low to …
The HIV protease enzyme (maturation enzyme) is one of the most promising therapeutic targets for the treatment of AIDS. Due to the mutation in the virus, there is always room for …