Background: In cross-sectional studies, elevated plasma total homocysteine (tHcy)
concentrations have been associated with cognitive impairment and dementia. Incidence …

Background In cross-sectional studies, elevated plasma homocysteine levels have been
associated with poor cognition and dementia. Studies of newly diagnosed dementia are …

Background: High concentrations of homocysteine have been linked to a greater risk of
Alzheimer disease, dementia, and cognitive decline. Objective: We evaluated the …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

BACKGROUND: Prospective cohort studies have not been consistent in showing an
association between serum homocysteine and dementia. OBJECTIVE: To conduct a meta …

Background Evidence supports an independent association between plasma total
homocysteine concentrations and the risk of vascular disease. Recent epidemiologic studies …

Background: Elevated plasma total homocysteine (tHcy) concentrations are common in the
elderly and have been suggested to be a risk factor for dementia. Objective: In an elderly …

Homocysteine (Hcy) is a risk factor for brain atrophy, cognitive impairment, and dementia.
Vitamin B12 and folate are cofactors necessary for the methylation of Hcy. However, there is …

Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Elderly subjects with mild cognitive impairment have a high risk for conversion to
Alzheimer's disease or are already in a preclinical dementia stage. By cross-sectionally …