Biophysical mechanisms responsible for pulsed low-level laser excitation of neural tissue

J Wells, C Kao, P Konrad… - … with tissue and …, 2006 - spiedigitallibrary.org
Background/Objective: The traditional method of stimulating neural activity has been based
on electrical methods and remains the gold standard to date despite inherent limitations. We …

Biophysical mechanisms of transient optical stimulation of peripheral nerve

J Wells, C Kao, P Konrad, T Milner, J Kim… - Biophysical journal, 2007 - cell.com
A new method for in vivo neural activation using low-intensity, pulsed infrared light exhibits
advantages over standard electrical means by providing contact-free, spatially selective …

Combined optical and electrical stimulation of neural tissue in vivo

AR Duke, JM Cayce, JD Malphrus… - … of biomedical optics, 2009 - spiedigitallibrary.org
Low-intensity, pulsed infrared light provides a novel nerve stimulation modality that avoids
the limitations of traditional electrical methods such as necessity of contact, presence of a …

Optical stimulation of neural tissue in vivo

J Wells, C Kao, K Mariappan, J Albea, ED Jansen… - Optics letters, 2005 - opg.optica.org
For more than a century, the traditional method of stimulating neural activity has been based
on electrical methods, and it remains the gold standard to date. We report a technological …

Transient and selective suppression of neural activity with infrared light

AR Duke, MW Jenkins, H Lu, JM McManus, HJ Chiel… - Scientific reports, 2013 - nature.com
Abstract Analysis and control of neural circuitry requires the ability to selectively activate or
inhibit neurons. Previous work showed that infrared laser light selectively excited neural …

Application of infrared light for in vivo neural stimulation

J Wells, C Kao, ED Jansen, P Konrad… - … of biomedical optics, 2005 - spiedigitallibrary.org
A novel method for damage-free, artifact-free stimulation of neural tissue using pulsed, low-
energy infrared laser light is presented. Optical stimulation elicits compound nerve and …

Infrared Nerve Stimulation: a novel therapeutic laser modality

JD Wells, JM Cayce, A Mahadevan-Jansen… - … -thermal response of …, 2010 - Springer
Neural stimulation is the process of activating neurons using an external source to evoke
action potential propagation down an axon. Electrical, chemical, thermal, optical, and …

Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation

HJ Feng, C Kao, MJ Gallagher, ED Jansen… - Journal of neuroscience …, 2010 - Elsevier
Transient electrical impulses are conventionally used to elicit physiological responses in
excitable tissues. While electrical stimulation has many advantages, it requires an electrode …

In vitro neuronal depolarization and increased synaptic activity induced by infrared neural stimulation

B Entwisle, S McMullan, P Bokiniec, S Gross… - Biomedical Optics …, 2016 - opg.optica.org
Neuronal responses to infrared neural stimulation (INS) are explored at the single cell level
using patch-clamp electrophysiology. We examined membrane and synaptic responses of …

Frontiers in optical stimulation of neural tissues: past, present, and future

J Wells, M Bendett, J Webb, C Richter… - … with Tissue and …, 2008 - spiedigitallibrary.org
Since lasers were first used in medicine and biomedical related research there have been a
variety of documented effects following the irradiation of neural tissues. The first systematic …