The organization and dynamics of chromatin fiber play crucial roles in regulating DNA
accessibility for gene expression. Here we combine cryoelectron tomography (cryo-ET), sub …

The naked DNA inside the nucleus interacts with proteins and RNAs forming a higher order
chromatin structure to spatially and temporally control transcription in eukaryotic cells. The …

The structure of chromatin plays pivotal roles in regulating gene transcription, DNA
replication and repair, and chromosome segregation. This structure, however, remains …

The hierarchical packaging of eukaryotic chromatin plays a central role in transcriptional
regulation and other DNA-related biological processes. Here, we report the 11-angstrom …

Highlights•Cryo-electro microscopy reveals the native conformation of chromatin fiber both
in vitro and in situ.•Presence of linker histone and ionic conditions determines the level of …

Genomic DNA is hierarchically packaged into chromatin in eukaryotes. As a central‐level
chromatin structure between nucleosomal arrays and higher order organizations, 30 nm …

Chromatin folding in eukaryotes fits the genome into the limited volume of the cell nucleus.
Formation of higher-order chromatin structures attenuates DNA accessibility, thus …

Since Flemming described a nuclear substance in the nineteenth century and named it
“chromatin,” this substance has fascinated biologists. What is the structure of chromatin …

In eukaryotes, higher-order chromatin organization is spatiotemporally regulated as
domains, for various cellular functions. However, their physical nature in living cells remains …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …