The mechanisms of neuronal injury after hypoxia–ischemia (HI) are different in the immature
and the adult brain, but microglia activation has not been compared. The purpose of this …

In the present study, we tested whether the ongoing differentiation of microglia in the
immature brain results in more robust microglial activation and pro-inflammatory responses …

We previously found increased microglial proliferation and pro-inflammatory cytokine
release in infant mice compared to juvenile mice after hypoxia–ischemia (HI). The aim of the …

The effects of hypoxia-ischemia (HI) on proliferation and differentiation in the immature
(postnatal day 9) and juvenile (postnatal day 21) mouse hippocampus were investigated by …

Background: Perinatal asphyxia, leading to neonatal encephalopathy, is one of the leading
causes for child mortality and long-term morbidities. Neonatal encephalopathy rates are …

Background: Neonatal encephalopathy induced by perinatal asphyxia is a serious condition
associated with high mortality and morbidity. Inflammation after the insult is thought to …

Understanding the evolution of neonatal hypoxic/ischemic is essential for novel
neuroprotective approaches. We describe the neuropathology and glial/inflammatory …

Hypoxic‐ischemic encephalopathy (HIE) mainly affects preterm and term newborns, leading
to a high risk of brain damage. Coexisting infection/inflammation and birth asphyxia are key …

Background Neuroinflammation plays an important role in ischemic brain injury and
recovery, however the interplay between brain development and the neuroinflammatory …

Background Neuroinflammation plays an important role in neonatal hypoxic-ischemic
encephalopathy (HIE). Although microglia are largely responsible for injury-induced …