The discovery by Kool and co-workers that 2, 4-difluorotoluene (F) mimics thymine (T) in
DNA replication has led to a controversy about the question if this mimic has the capability of …

The discovery by Kool and coworkers that 2, 4‐difluorotoluene (F) mimics thymine (T) in
DNA replication has led to controversy regarding the question of whether this mimic has the …

Based on a series of elegant experiments, Kool and coworkers [1] concluded that not
Watson±Crick hydrogen bonding but steric effects, that is, the shape of DNA bases is mainly …

Recent experiments have shown that difluorotoluene (F), a nonpolar isostere for thymine (T),
codes efficiently and specifically for adenine (A) in DNA replication. F has almost the same …

We address the recent debate surrounding the ability of 2, 4-difluorotoluene (F), a low-
polarity mimic of thymine (T), to form a hydrogen-bonded complex with adenine in DNA. The …

Up till now, there has been a significant disagreement between theory and experiment
regarding hydrogen bond lengths in Watson− Crick base pairs. To investigate the possible …

We have theoretically analyzed mimics of Watson-Crick AT and GC base pairs in which
NH··· O hydrogen bonds are replaced by NH··· S, using the generalized gradient …

Calculations were run on the methylated DNA base pairs adenine: thymine and adenine:
difluorotoluene to further investigate the hydrogen-bonding properties of difluorotoluene (F) …

We challenge the view that the hydrogen bonds in Watson–Crick AT and GC base pairs are
in essence electrostatic interactions with substantial resonance assistance from the π …

We have theoretically analyzed a complete series of Watson–Crick and mismatched DNA
base pairs, both in gas phase and in solution. Solvation causes a weakening and …