In the study reported here, we determined the effects on bone healing of rofecoxib, one of
the selective cyclooxygenase-2 (Cox-2) inhibitors that has been used for postsurgical …

Since their approval by the FDA and introduction in 1999, COX-2 inhibitors have rapidly
become the 11th-largest therapeutic class of drugs in the US In 2000, Celebrex (celecoxib) …

NON-STEROIDAL ANTI-INFLAMMATORY drugs (NSAIDs) are among the most commonly
prescribed drugs worldwide. Indicated in the treatment of several forms of arthritis, menstrual …

We have evaluated the effect of the short-term administration of low therapeutic doses of
modern COX-2 inhibitors on the healing of fractures. A total of 40 adult male New Zealand …

Prostaglandins are important mediators of bone repair, and cyclooxygenases are required
for prostaglandin production. Data from animal studies suggest that both non-specific and …

Background and purpose Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit
cyclooxygenase (COX) activity, which is the rate-limiting enzyme in the synthesis of …

Background: Nonsteroidal anti-inflammatory medications have been shown to delay fracture-
healing. COX-2-specific inhibitors such as celecoxib have recently been approved for …

In the article “Diferential inhibition of fracture healing by non-selective and cyclooxygenuse-
2 selective nonsteroidal anti-injlanznzatory drugs”[2], Gerstenfeld et al. conclude in the …

Background: The effects of cyclooxygenase (COX) inhibition on fracture healing are
insufficiently documented, and the aim of this study was to evaluate the effects of nonspecific …

Since the advent of cyclooxygenase 2 (COX-2) inhibitors, little research has been done on
the effects of these medications on fracture healing. In the study reported here, we sought to …