As one of the most induced genes in activated macrophages, immune-responsive gene 1
(IRG1) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid …

Varieties of RNA modification form the epitranscriptome for post-transcriptional regulation. 5-
Methylcytosine (5-mC) is a sparse RNA modification in messenger RNA (mRNA) under …

TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumour
suppressor activity in many types of cancers. Even in the absence of TET coding region …

Immune-responsive gene 1 (IRG1) encodes aconitate decarboxylase (ACOD1) that
catalyzes the production of itaconic acids (ITAs). The anti-inflammatory function of IRG1/ITA …

Following activation, macrophages undergo extensive metabolic rewiring,. Production of
itaconate through the inducible enzyme IRG1 is a key hallmark of this process. Itaconate …

Epigenetic modifiers have fundamental roles in defining unique cellular identity through the
establishment and maintenance of lineage-specific chromatin and methylation status …

Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine
(5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial …

Epigenetic regulation of lineage-specific genes is important for the differentiation and
function of T cells. Ten-eleven translocation (Tet) proteins catalyze 5-methylcytosine (5mC) …

Cytosolic mitochondrial DNA (mtDNA) elicits a type I interferon response, but signals
triggering the release of mtDNA from mitochondria remain enigmatic. Here, we show that …

Macrophages play a central role in innate immunity as the first line of defense against
pathogen infection. Upon exposure to inflammatory stimuli, macrophages rapidly respond …