Foxp3 has been shown to be both necessary and sufficient for the development and function
of naturally arising CD4+ CD25+ regulatory T cells in mice. Mutation of Foxp3 in Scurfy mice …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

FOXP3 has been identified as a key regulator of immune homeostasis. Mutations within the
FOXP3 gene result in dysregulated CD4+ T‐cell function and elevated cytokine production …

The forkhead family transcription factor FOXP3 has been shown to be critical for the
development and function of CD4+ CD25+ regulatory T cells. Recently, FOXP3 expression …

The immune system has evolved mechanisms to recognize and eliminate threats, as well as
to protect against self-destruction. Tolerance to self-antigens is generated through two …

Foxp3 is a transcription factor required for the development of regulatory T cells (Treg). Mice
and humans with a loss of Foxp3 function suffer from uncontrolled autoimmunity and …

Foxp3 plays a key role in CD4+ CD25+ Treg cell function in mice and represents a specific
marker for these cells. Despite the strong association between FOXP3 expression and …

Regulatory T cells are capable of suppressing deleterious immune responses against self-or
non-self-antigens. Their essential role in tolerance and immune regulation has been …

Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the
genetic program governing CD25+ CD4+ regulatory T cell (Tr) development and function in …