Effects of PDE inhibitors and carbachol on the L-type Ca current in guinea pig ventricular myocytes

K Mubagwa, T Shirayama, M Moreau… - American Journal of …, 1993 - journals.physiology.org
The phosphodiesterase inhibitors 3-isobutyl-1-methylxanthine (IBMX; 100 microM) and
papaverine (100 microM) increased peak L-type Ca current (ICa) more than fivefold in a way …

[PDF][PDF] Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes.

MA Simmons, HC Hartzell - Molecular pharmacology, 1988 - Citeseer
It has previously been shown that intracellular perfusion of isolated cardiac myocytes with
cGMP reduces the amplitude of the trans-sarcolemmal calcium current (ICa) elevated by …

Inhibition in L-type Ca2+ channel by stimulation of protein kinase C in isolated guinea pig ventricular cardiomyocytes.

H Satoh - General pharmacology, 1992 - europepmc.org
1. Electrophysiological effects of phorbol esters on the L-type Ca2+ current (ICa (L)) in
isolated single ventricular cells from guinea pig hearts were investigated. 2. In whole-cell …

The calcium antagonist D600 inhibits calcium‐independent transient outward current in isolated rat ventricular myocytes.

IA Lefevre, A Coulombe… - The Journal of …, 1991 - Wiley Online Library
1. The whole‐cell voltage‐clamp technique was applied to isolated rat ventricular myocytes
to investigate the effects of D600 (10 (‐9)‐10 (‐3) M) on the intracellular calcium …

β‐adrenergic and muscarinic agonists modulate inactivation of l‐type ca2+ Channel Currents in Guinea‐Pig Ventricular Myocytes

I Findlay - The Journal of physiology, 2002 - Wiley Online Library
The objective of this study was to examine the effects of isoproterenol (isoprenaline) and
carbachol upon voltage‐dependent inactivation of L‐type Ca2+ current (ICa, L). ICa, L was …

Effects of propafenone on calcium current in guinea-pig ventricular myocytes.

C Delgado, J Tamargo, D Henzel… - British journal of …, 1993 - ncbi.nlm.nih.gov
The modulation of L-type voltage-sensitive calcium channels in guinea-pig isolated
ventricular myocytes by propafenone was examined by the whole cell voltage-clamp …

Multiple modulations of action potential duration by different calcium channel blocking agents in guinea pig ventricular myocytes

S Zhang, T Sawanobori, Y Hirano… - Journal of …, 1997 - journals.lww.com
Abstract Effects of extracellular applications of different types of Ca 2+ channel blocking
agents (Mn 2+, verapamil, and nisoldipine) on action-potential duration and membrane …

Elevated cAMP suppresses muscarinic inhibition of L-type calcium current in guinea pig ventricular myocytes

R Sakai, JB Shen, AJ Pappano - Journal of cardiovascular …, 1999 - journals.lww.com
We investigated the effect of carbachol (CCh) on L-type Ca 2+ current (I Ca (L)) enhanced
by dialyzed adenosine 3′, 5′-cyclic monophosphate (cAMP) and/or bath-applied 3 …

Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes

JW Wegener, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1995 - Springer
The effects of the phenylalkylamines verapamil, gallopamil, and devapamil on L-type
calcium currents (I Ca) were studied in ventricular myocytes from rat hearts using the whole …

Modulation of basal L‐type Ca2+ current by adenosine in ferret isolated right ventricular myocytes.

Y Qu, DL Campbell, AR Whorton… - The Journal of …, 1993 - Wiley Online Library
1. The whole‐cell configuration of the gigaohm seal voltage clamp and an internal perfusion
technique were used to study the effects of adenosine on the basal L‐type Ca2+ current …