The last years have witnessed rapid progress in our understanding of chromatin structure at
the nucleosome or beads-on-a-string level (Elgin and Weintraub 1975; Kornberg 1977) …

Both intact and nuclease-isolated chromatin fibers have been examined at different degrees
of salt-induced compaction, using a variety of preparation techniques. The results suggest …

There now seems to be little doubt that DNA in the nucleus of eukaryotic cells is in the form
of very long, continuous molecules, probably thousands of times as long as the largest …

The DNA helix is coiled in the nucleohistone fiber in a nonrandom, precise manner. At one
end of the coiling spectrum we have the nucleosome and at the other end the metaphase …

There is considerable current interest in the organisation of nucleosomes in chromatin. A
strong X-ray and neutron semi-meridional diffraction peak at approximately 10 nm had …

In this paper, we show that HeLa metaphase chromosomes still possess a highly organized
structure retaining the familiar metaphase morphology following removal of virtually all the …

The three dimensional (3D) structure of chromatin fibers in sections of nuclei has been
determined using electron tomography. Low temperature embedding and nucleic acid …

The question as to how the strands of chromatin are packed into the eukaryotic nucleus has
intrigued biologists and biochemists for many years. Although there is ample space in the …

The predominant view of chromatin structure is that the beaded chain of nucleosomes is
folded into a symmetrical helical fibre. Recently, however, direct evidence from cryoelectron …

Each level of DNA folding in cells corresponds to a distinct chromatin structure. The basic
chromatin units, nucleosomes, are arranged into solenoids which form chromatin loops. To …