Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2
The actin-related protein (Arp) 2/3 complex is an essential regulator of de novo actin filament
formation. Arp2/3 nucleates the polymerization of actin and creates branched actin filaments …
formation. Arp2/3 nucleates the polymerization of actin and creates branched actin filaments …
Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin …
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an essential regulator of actin
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It …
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It …
Arp2/3 complex is bound and activated by two WASP proteins
SB Padrick, LK Doolittle… - Proceedings of the …, 2011 - National Acad Sciences
Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP
GOC Cory, R Cramer, L Blanchoin, AJ Ridley - Molecular cell, 2003 - cell.com
Wiskott-Aldrich syndrome protein (WASP) and neural (N)-WASP regulate dynamic actin
structures through the ability of their VCA domains to bind to and stimulate the actin …
structures through the ability of their VCA domains to bind to and stimulate the actin …
Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex
JF Gaucher, C Maugé, D Didry, B Guichard… - Journal of Biological …, 2012 - ASBMB
Wiskott-Aldrich syndrome proteins (WASP) are a family of proteins that all catalyze actin
filament branching with the Arp2/3 complex in a variety of actin-based motile processes. The …
filament branching with the Arp2/3 complex in a variety of actin-based motile processes. The …
Requirement of the basic region of N-WASP/WAVE2 for actin-based motility
WASP family proteins activate nucleation by the Arp2/3 complex, inducing rapid actin
polymerization in vitro. Although the C-terminal portion of WASP family proteins (VCA) …
polymerization in vitro. Although the C-terminal portion of WASP family proteins (VCA) …
Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex
M Rodnick-Smith, Q Luan, SL Liu… - Proceedings of the …, 2016 - National Acad Sciences
The Arp2/3 (Actin-related proteins 2/3) complex is activated by WASP (Wiskott–Aldrich
syndrome protein) family proteins to nucleate branched actin filaments that are important for …
syndrome protein) family proteins to nucleate branched actin filaments that are important for …
Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation …
All WASP family proteins share a common C terminus that consists of the verprolin
homology domain (V), cofilin homology domain (C), and acidic region (A), through which …
homology domain (V), cofilin homology domain (C), and acidic region (A), through which …
WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell mov
T Takenawa, H Miki - Journal of cell science, 2001 - journals.biologists.com
Reorganization of cortical actin filaments plays critical roles in cell movement and pattern
formation. Recently, the WASP and WAVE family proteins WASP and N-WASP, and WAVE1 …
formation. Recently, the WASP and WAVE family proteins WASP and N-WASP, and WAVE1 …
Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging
BA Smith, K Daugherty-Clarke… - Proceedings of the …, 2013 - National Acad Sciences
Actin filament nucleation by actin-related protein (Arp) 2/3 complex is a critical process in
cell motility and endocytosis, yet key aspects of its mechanism are unknown due to a lack of …
cell motility and endocytosis, yet key aspects of its mechanism are unknown due to a lack of …