The global spread of bacterial antimicrobial resistance is associated to millions of deaths
from bacterial infections per year, many of which were previously treatable. This, combined …

The disturbing increase in the number of bacterial pathogens that are resistant to multiple, or
sometimes all, current antibiotics highlights the desperate need to pursue the discovery and …

Bacterial resistance to antibiotics makes previously manageable infections again disabling
and lethal, highlighting the need for new antibacterial strategies. In this regard, inhibition of …

Essential cell division protein FtsZ is considered an attractive target in the search for
antibacterials with novel mechanisms of action to overcome the resistance problem. FtsZ …

The widespread problem of bacterial resistance towards existing drugs and the paucity of
effective drugs for the treatment of bacterial infections have prompted the scientific …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

The bacterial cell division protein FtsZ is one of many potential targets for the development
of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; …

The bacterial cell division protein FtsZ is an attractive target for small-molecule antibacterial
drug discovery. Derivatives of 3-methoxybenzamide, including compound PC190723, have …

FtsZ is the key protein of bacterial cell division and an emergent target for new antibiotics. It
is a filament-forming GTPase and a structural homologue of eukaryotic tubulin. A number of …