Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting innate immune responses. The deleterious effects of inflammasome activation have been …
TS Rodrigues, DS Zamboni - Current Opinion in Immunology, 2023 - Elsevier
Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3 inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a great threat to global public health since 2020. Although the advance on vaccine …
J Courjon, O Dufies, A Robert, L Bailly, C Torre… - Blood …, 2021 - ashpublications.org
Dysregulated immune response is the key factor leading to unfavorable coronavirus disease 2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the …
M Yalcinkaya, W Liu, MN Islam, AG Kotini… - Scientific reports, 2021 - nature.com
Despite the initial success of some drugs and vaccines targeting COVID-19, understanding the mechanism underlying SARS-CoV-2 disease pathogenesis remains crucial for the …
Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …