Bioprosthetic heart valves are widely used because of their low risk of thromboembolic
complications. The major limitation to the longterm success of these prostheses is caused by …

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

All types of contemporary cardiac valve substitutes suffer deficiencies and complications that
limit their success. Mechanical and bioprosthetic valves are intrinsically obstructive …

Cardiac valve replacement with mechanical prosthetic or bioprosthetic devices enhances
patient survival and quality of life. Nevertheless, prosthesis‐associated complications are …

Background. Tissue properties may contribute to intrinsic calcification of bioprosthetic heart
valves. Phospholipids have been proposed as potential nucleation sites for calcification …

Clinical and experimental studies indicate that calcification of bioprosthetic valves depends
on host, implant, and biomechanical factors. The earliest mineral deposits in both clinical …

Methods A total of 60 explanted porcine bioprosthetic valves was tested mechanically, and
15 explanted valves were examined grossly and histologically. Circumferentially and …

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Substitute heart valves composed of human or animal tissues have been used since the
early 1960s, when aortic valves obtained fresh from human cadavers were transplanted to …

Valve replacement started in 1960, with the surgeon now having a significant variety of
prosthetic heart valves from which to choose. These valves are broadly divided into …