High levels of homocysteine are reported as a risk factor for Alzheimer's disease (AD).
Correspondingly, inborn hyperhomocysteinemia is associated with an increased …

The accumulation of various metabolites appears to be associated with diverse human
diseases. However, the aetiological link between metabolic alteration and the observed …

Previous works reported that a mild increase in homocysteine level is a risk factor for
cardiovascular and neurodegenerative diseases in humans. Homocysteine thiolactone is a …

Hyperhomocysteinemia has recently been identified as an important risk factor for
Alzheimer's disease (AD). One of the potential mechanisms underlying harmful effects of …

Recent epidemiological and clinical data suggest that elevated serum homocysteine levels
may increase the risk of developing Alzheimer's disease (AD), but the underlying …

Objective High level of homocysteine (Hcy) is a recognized risk factor for developing
Alzheimer disease (AD). However, the mechanisms involved are unknown. Previously, it …

Abstract α-Synuclein (α-syn), as a primary pathogenic protein in Parkinson's disease (PD)
and other synucleinopathies, exhibits a high potential to form polymorphic fibrils. Chemical …

Disturbed homocysteine metabolism may contribute to amyloidogenesis by modulating the
amyloid precursor protein (APP) production and processing. The objective of this study was …

Protofibrils are transient structures observed during in vitro formation of mature amyloid
fibrils and have been implicated as the toxic species responsible for cell dysfunction and …

Amyloid-β amyloidogenesis is reported to occur via a nucleated polymerization mechanism.
If this is true, the energetically unfavorable oligomeric nucleus should be very hard to detect …