We report here the efficacy of tumor‐targeting Salmonella typhimurium A1‐R (A1‐R) on
mouse models of disseminated and metastatic ovarian cancer. The proliferation‐inhibitory …

Peritoneal disseminated cancer is highly treatment resistant. We here report the efficacy of
intraperitoneal (ip) administration of tumor-targeting Salmonella typhimurium A1-R in a nude …

We developed the tumor-targeting strain Salmonella typhimuium A1-R (A1-R) and have
shown it to be active against a number of tumor types in nude mice. However, in …

Background/Aims: We previously developed a genetically-modified bacterial strain of
Salmonella typhimurium, auxotrophic for leucine and arginine, which also expresses green …

We have developed the genetically-modified Salmonella typhimurium A1-R strain that
selectively targets tumors. S. typhimurium A1-R is auxotrophic for Leu and Arg, which …

The present study determined the effect of the tumor‐targeting strain Salmonella
typhimurium A1‐R (S. typhimurium A1‐R) on CD8+ tumor‐infiltrating lymphocytes (TILs) in a …

We have developed a bacterial cancer therapy strategy using the genetically-engineered
strain Salmonella typhimurium A1-R (A1-R). A1-R is auxotrophic for leu and arg which …

We developed tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R, a facultative
anaerobe that is an auxotroph of leucine and arginine. The tumor-targeting efficacy of S …

Quiescent cancer cells are resistant to cytotoxic agents which target only proliferating cancer
cells. Time-lapse imaging demonstrated that tumor-targeting Salmonella typhimurium A1-R …

The present authors have previously reported a novel approach to genetically engineer
Salmonella typhimurium for the medically important therapeutic strategy of using bacterial …