Osteoclasts have been shown to produce reactive oxygen intermediates (ROI) and it has
been suggested that ROI are involved in the process of bone resorption. ROI have also been …

Several bone resorptive stimuli affect osteoclasts indirectly by modulating the production
and release of osteoblastic factors. Using electrophoretic mobility shift assays, we found that …

The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

Osteoclasts have been shown to destroy calcified tissue by complex developmental steps
involving cell recruitment, cell attachment and deployment of multiple enzymes. They also …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

Reactive oxygen species (ROS) and free radicals are essential for transmission of cell
signals and other physiological functions. However, excessive amounts of ROS can cause …

Oxygen derived free radicals are generated by osteoclasts. In a novel culture system,
isolated rat osteoclasts were stained when nitroblue tetrazolium (NBT) was reduced by …

We have examined the role of prostaglandins, nitric oxide (NO), and the NO induced effector
molecule cyclic-guanosine monophosphate (cGMP) as mediators of cytokine effects on …

Abstract Interferon‐γ (IFN‐γ) has been shown to inhibit interleukin‐1 (IL‐1) and tumor
necrosis factor α (TNF‐α) stimulated bone resorption by strongly stimulating nitric oxide (NO) …

It has been established that reactive oxygen species (ROS) such as H 2 O 2 or superoxide
anion is involved in bone loss-related diseases by stimulating osteoclast differentiation and …