Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …

Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet
activation, high plasma levels of markers of thrombin generation, depletion of natural …

Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting
millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and …

Sickle cell disease is the most common inherited haematological disorder that leads to the
irreversible damage of multiple organs. Although sickling of red blood cells and vaso …

Sickle cell disease (SCD) is a hematologic disorder caused by a well‐characterized point
mutation in the β‐globin gene. Abnormal polymerization of hemoglobin tetramers results in …

Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has
the unique property of polymerizing when deoxygenated. The pathophysiology of acute and …

There is evidence of activation of both blood coagulation and platelets in sickle cell disease.
For example, plasma samples obtained in the steady state and during painful crisis …

Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin
generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic …

Sickle cell disease, the most common genetic blood disorder in the world, has high clinical
variability, negatively impacts quality of life and contributes to early mortality. Sickled …

Essentials• Sickle cell disease is increasingly being recognized as a chronic
hypercoagulable state.• Thrombin generation is elevated in the whole blood, but not the …