Purpose To find a relationship between absence of annulus and asthenozoospermia in
Iranian men. Methods In the present study, semen samples from 100 asthenozoospermic …

Purpose: Septins are the major constituents of the annulus, a submembranous ring that
separates the middle and principal pieces of spermatozoa. We previously reported its …

Background The annulus is a ring-shaped structure located beneath the plasma membrane
that connects the midpiece and the principal piece of mammalian sperm flagellum. It has …

SEPT12 is a testis‐specific gene involved in the terminal differentiation of male germ cells.
SEPT12 protein is required for sperm head‐tail formation and acts as a fundamental …

Asthenoteratozoospermia is the primary cause of infertility in humans. However, the genetic
etiology remains largely unknown for those suffering from severe asthenoteratozoospermia …

Methods Samples of ejaculated sperm from idiopathic asthenozoospermia patients and
normozoospermic men were separated and purified by Percoll discontinuous density …

Septins are members of the GTPase superfamily, which has been implicated in diverse
cellular functions including cytokinesis and morphogenesis. Septin 12 (SEPT12) is a testis …

Background and aims Motility and morphological defects of spermatozoa can cause male
infertility. Sperm RNAs are related to sperm quality. They are considered to have clinical …

The annulus is a septin-based ring structure located at the junction of the midpiece (MP) and
the principal piece (PP) of spermatozoa flagellum. In the mouse, deletion of Septin 4, a …

Background: Septins are an evolutionary conserved group of GTP-binding and filament-
forming proteins that have diverse cellular roles. An increasing body of data implicates the …