The advent of ribosome profiling and other tools to probe mRNA translation has revealed
that codon bias—the uneven use of synonymous codons in the transcriptome—serves as a …

Messenger RNA (mRNA) translation by the ribosome represents the final step of a
complicated molecular dance from DNA to protein. Although classically considered a …

Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the
post-transcriptional process that profoundly impact protein production in a cell. While it is …

Summary mRNA degradation represents a critical regulated step in gene expression.
Although the major pathways in turnover have been identified, accounting for disparate half …

mRNA translation decodes nucleotide into amino acid sequences. However, translation has
also been shown to affect mRNA stability depending on codon composition in model …

Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …

Synonymous codons encode the same amino acid, but differ in other biophysical properties.
The evolutionary selection of codons whose properties are optimal for a cell generates the …

The central dogma of molecular biology entails that genetic information is transferred from
nucleic acid to proteins. Notwithstanding retro-transcribing genetic elements, DNA is …

Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …

Codon usage and tRNA abundance are critical parameters for gene synthesis. However, the
forces determining codon usage bias within genomes and between organisms, as well as …