The global cancer burden is growing and accounted for 10 million deaths in 2020. The
resurgence of chemo-and radiation resistance have contributed to the treatment failures in …

A paradigm change in the treatment of cancer is urgently needed. Bacteria offer many
advantages, including natural cytotoxity, motility, chemotaxis and a relative large genome to …

We report here a modified auxotrophic strain of Salmonella typhimurium that can target and
cure breast tumors in orthotopic mouse models. We have previously reported development …

Bacterial infection occasionally has a marked therapeutic effect on malignancies, as noted
as early as the 19th century. Recently, there have been attempts to develop cancer …

The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic
strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor …

We have developed an effective bacterial cancer therapy strategy by targeting viable tumor
tissue using Salmonella typhimurium auxotrophs that we have generated which grow in …

Introduction: The potential of bacteria as therapeutics for cancer has a long history, dating at
least as far back as the early 19th Century. Bacteria have a large genome that can be …

Salmonella typhimurium double leu-arg auxotrophs have been shown to be highly effective
as antitumor agents in nude mouse models of human metastatic cancer. In order to proceed …

We have developed the genetically-modified Salmonella typhimurium A1-R strain that
selectively targets tumors. S. typhimurium A1-R is auxotrophic for Leu and Arg, which …

Background/Aim: Cancer treatment with attenuated Salmonella enterica Typhimurium (S.
Typhimurium) has gained momentum in recent years. However, the effectiveness of this …