1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

The antiarrhythmic drug quinidine has been shown to block several types of K+ channel
currents in cardiac preparations including the transient outward current (Ito). To characterize …

The modes in which quinidine blocks the delayed K current (1K) of rabbit sinoatrial and
atrioventricular nodes were investigated by voltage clamp experiments using small …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

The interaction of quinidine with a cloned human cardiac potassium channel (HK2)
expressed in a stable mouse L cell line was studied using the whole-cell tight-seal voltage …

We examined the effects of quinidine (5-20 microM) on transmembrane action potentials
and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine …

A major action of the antiarrhythmic agent quinidine is prolongation of cardiac repolarization.
In these experiments, the time-dependent effects of quinidine on the delayed rectifier …

Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac
rhythm disturbances. It depresses the rapid initial depolarization of the action potential by …

In guinea pig cardiac myocytes quinidine (20 microM) caused less than 10% tonic block
reduction of the sodium current at-120 mV, but a fast pulse train reduced it more than 90 …