Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4+
FOXP3+ regulatory T (Treg) cells. Human Treg cells express several different isoforms of …

Foxp3 has been shown to be both necessary and sufficient for the development and function
of naturally arising CD4+ CD25+ regulatory T cells in mice. Mutation of Foxp3 in Scurfy mice …

Regulatory T (Treg) cells are essential in preventing the host from developing certain
autoimmune diseases and limiting excessive immune responses against pathogens. The …

FOXP3 has been identified as a key regulator of immune homeostasis. Mutations within the
FOXP3 gene result in dysregulated CD4+ T‐cell function and elevated cytokine production …

Foxp3 is a transcription factor required for the development of regulatory T cells (Treg). Mice
and humans with a loss of Foxp3 function suffer from uncontrolled autoimmunity and …

While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is
unclear how the mutant protein fails to function as a transcriptional regulator. There is also …

Abstract CD4+ CD25+ regulatory T cells are essential for the active suppression of
autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically …

Regulatory T cells are capable of suppressing deleterious immune responses against self-or
non-self-antigens. Their essential role in tolerance and immune regulation has been …