Objective To characterize the course of cognitive decline during the prodromal phase of
Alzheimer disease. Design Longitudinal cohort study with up to 16 years of observation …

Two subtypes of Alzheimer's disease (AD) have been commonly identified: early-and late-
onset forms. Previous studies suggest that early-onset AD patients have more neuritic …

Objective: To investigate the neurocognitive measures that best predict progression from
amnestic mild cognitive impairment (aMCI) to Alzheimer disease (AD). Methods: We …

Background Detection of the earliest cognitive changes signifying Alzheimer disease is
difficult. Objective To model the cognitive decline in preclinical Alzheimer disease. Design …

Objective To examine change in cognitive function in older persons sampled from a
community population, and its relation to age and Alzheimer disease. Design Prospective …

Objective: To determine if individuals ultimately diagnosed with Alzheimer disease (AD)
exhibited evidence of cognitive impairment on neuropsychological tests administered …

Objective Some individuals who are asymptomatic for dementia while alive have substantial
Alzheimer's disease (AD) neuropathology at autopsy. We investigated whether cognitive …

Objective Whereas cognitive deficits are known to be detectable long before the typical
symptoms of Alzheimer's disease (AD) are evident, previous studies have failed to …

Background To understand the earliest signs of cognitive decline caused by Alzheimer
disease (AD) and other illnesses causing dementia, information is needed from well …

Background Mild cognitive impairment (MCI) is considered to be a transitional stage
between aging and Alzheimer disease (AD). Objective To determine whether MCI …