Elevated microglial/macrophage-associated biomarkers in the cerebrospinal fluid of infant
victims of abusive head trauma (AHT) suggest that these cells play a role in the …

The role of microglia in the pathophysiology of injury to the developing brain has been
extensively studied. In children under the age of 4 who have sustained a traumatic brain …

Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

Neurogenesis is stimulated following injury to the adult brain and could potentially contribute
to tissue repair. However, evidence suggests that microglia activated in response to injury …

Traumatic brain injury (TBI) causes a wide spectrum of consequences, such as microglial
activation, cerebral inflammation, and focal and diffuse brain injury, as well as functional …

An increase in the number of activated microglia in the brain is a key feature of
neuroinflammation after a hypoxic–ischemic insult to the preterm neonate and can …

Mild traumatic brain injury afflicts over 2 million people annually and little can be done for
the underlying injury. The Food and Drug Administration-approved drugs Minocycline plus N …

To investigate whether minocycline provides long‐lasting protection against neonatal
hypoxia–ischemia‐induced brain injury and neurobehavioral deficits, minocycline was …

Preferential brain white matter injury and hypomyelination induced by intracerebral
administration of the endotoxin lipopolysaccharide (LPS) in the neonatal rat brain has been …

There are no drugs to manage traumatic brain injury (TBI) presently. A major problem in
developing therapeutics is that drugs to manage TBI lack sufficient potency when dosed …