Poly (ADP-ribose) polymerase-1 (PARP-1; EC 2.4. 2.30) is an abundant nuclear enzyme,
activated by DNA strand breaks to attach up to 200 ADP-ribose groups to nuclear proteins …

The DNA-breaking and-joining steps initiating retroviral integration are well understood, but
the later steps, thought to be carried out by cellular DNA repair enzymes, have not been fully …

This study examined the efficiency of human immunodeficiency virus type 1 (HIV-1)
integration in poly (ADP-ribose) polymerase-1 (PARP-1)-deficient murine cells and in …

ABSTRACT Poly (ADP-ribose) polymerase 1 (PARP-1) is a cellular enzyme with a
fundamental role in DNA repair and the regulation of chromatin structure, processes …

Integration of proviral DNA into the host cell genome is a characteristic feature of the
retroviral life cycle. This process involves coordinate DNA strand break formation and …

Integration of a DNA copy of the viral RNA genome is a crucial step in the life cycle of human
immunodeficiency virus type 1 (HIV-1) and other retroviruses. While the virally encoded …

We established small interfering RNA (siRNA) directed against poly (ADP-ribose)
polymerase 1 (PARP-1) that effectively reduces the expression of PARP-1 in two human cell …

Most members of the poly (ADP-ribose) polymerase family, PARP family, have a catalytic
activity that involves the transfer of ADP-ribose from a beta-NAD+-molecule to protein …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …

Poly (ADP-ribosylation) is a post-translational covalent modification of proteins catalyzed by
a family of enzymes termed poly (ADP-ribose) polymerases (PARPs). In the human genome …