On the use of in-silico simulations to support experimental design: A case study in microbial inactivation of foods

A Garre, JL Peñalver-Soto, A Esnoz, A Iguaz… - PLoS …, 2019 - journals.plos.org
The mathematical models used in predictive microbiology contain parameters that must be
estimated based on experimental data. Due to experimental uncertainty and variability, they …

Guidelines for the design of (optimal) isothermal inactivation experiments

JL Peñalver-Soto, A Garre, A Esnoz… - Food Research …, 2019 - Elsevier
Kinetic models are nowadays a basic tool to ensure food safety. Most models used in
predictive microbiology have model parameters, whose precision is crucial to provide …

Optimal characterization of thermal microbial inactivation simulating non-isothermal processes

A Garre, G González-Tejedor, JL Peñalver-Soto… - Food Research …, 2018 - Elsevier
In this paper, optimal experimental design is applied for the characterization of the microbial
inactivation of Listeria monocytogenes under non-isothermal conditions, modelled by the …

Introducing optimal experimental design in predictive modeling: A motivating example

KJ Versyck, K Bernaerts, AH Geeraerd… - International Journal of …, 1999 - Elsevier
Predictive microbiology emerges more and more as a rational quantitative framework for
predicting and understanding microbial evolution in food products. During the mathematical …

Comparing experimental design schemes in predictive food microbiology: Optimal parameter estimation of secondary models

L Mertens, E Van Derlinden, JF Van Impe - Journal of Food Engineering, 2012 - Elsevier
In predictive food microbiology, full factorial designs are still more the rule than the
exception, despite the huge experimental workload and cost related to this method. In this …

Bioinactivation: Software for modelling dynamic microbial inactivation

A Garre, PS Fernández, R Lindqvist, JA Egea - Food Research International, 2017 - Elsevier
This contribution presents the bioinactivation software, which implements functions for the
modelling of isothermal and non-isothermal microbial inactivation. This software offers …

Optimal experimental design for discriminating between microbial growth models as function of suboptimal temperature: From in silico to in vivo

I Stamati, S Akkermans, F Logist, E Noriega… - Food Research …, 2016 - Elsevier
Temperature is an important food preservation factor, affecting microbial growth. Secondary
predictive models can be used for describing the impact of this factor on microbial growth. In …

Tail or artefact? Illustration of the impact that uncertainty of the serial dilution and cell enumeration methods has on microbial inactivation

A Garre, JA Egea, A Esnoz, A Palop… - Food Research …, 2019 - Elsevier
The estimation of the concentration of microorganisms in a sample is crucial for food
microbiology. For instance, it is essential for prevalence studies, challenge tests (growth …

Application of optimal experimental design concept to improve the estimation of model parameters in microbial thermal inactivation kinetics

MM Gil, FA Miller, CLM Silva, TRS Brandão - Journal of Food Engineering, 2014 - Elsevier
The estimation of model parameters with high precision is of major importance in
mathematical predictions. If a mathematical model is properly chosen and if the primary …

Computing optimal dynamic experiments for model calibration in predictive microbiology

E BALSA‐CANTO, AA Alonso… - Journal of Food Process …, 2008 - Wiley Online Library
The potential of mathematical models describing the microbial behavior during food
processing and storage largely depends on their predictive capabilities and, in this concern …