Lamina I spino-parabrachial neurons (SPNs) receive peripheral nociceptive input, process it
and transmit to the supraspinal centres. Although responses of SPNs to cutaneous receptive …

Projection neurons in the spinal dorsal horn relay sensory information to higher brain
centres. The activation of these populations is shaped by afferent input from the periphery …

Key points Spinal cord lamina I neurons receiving dense input from nociceptors and
projecting to the parabrachial area at the ponto‐mesencephalic junction form the major …

The dorsal horn of the spinal cord is the first integration site of somatosensory inputs from
the periphery. In the superficial layers of the dorsal horn, nociceptive inputs are processed …

The parabrachial nucleus (PBN) is one of the major targets of spinal projection neurons and
plays important roles in pain. However, the architecture of the spinoparabrachial pathway …

Key points Spinal lamina I is a key element of the pain processing system which relays
peripheral inputs to supraspinal areas. In this study, we focused on signal processing in …

The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the
amygdala for processing affective responses. However, it is unclear whether the LPBN …

Nociceptive signals are usually transmitted to layer 4 neurons in somatosensory cortex via
the spinothalamic-thalamocortical pathway. The layer 5 corticospinal neurons in …

The lateral parabrachial nucleus (LPBN) plays an important role in the processing and
establishment of pain aversion. It receives direct input from the superficial dorsal horn and …

Parallel Parabrachial Pathways Provide Pieces of the Pain Puzzle: Neuron Skip to Main Content
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