Comprehensive untargeted lipidomic analysis using core–shell C30 particle column and high field orbitrap mass spectrometer

M Narváez-Rivas, Q Zhang - Journal of Chromatography A, 2016 - Elsevier
The goal of untargeted lipidomics is to have high throughput, yet comprehensive and
unambiguous identification and quantification of lipids. Novel stationary phases in LC …

Off-line mixed-mode liquid chromatography coupled with reversed phase high performance liquid chromatography-high resolution mass spectrometry to improve …

M Narváez-Rivas, N Vu, GY Chen, Q Zhang - Analytica chimica acta, 2017 - Elsevier
The confident identification and in-depth profiling of molecular lipid species remain to be a
challenge in lipidomics analysis. In this work, an off-line two-dimensional mixed-mode and …

Rational selection of reverse phase columns for high throughput LC–MS lipidomics

A Criscuolo, M Zeller, K Cook, G Angelidou… - Chemistry and physics …, 2019 - Elsevier
Natural lipidomes are characterized by extremely high complexity and dynamic range of
lipid concentrations. Furthermore, high diversity of lipid physicochemical properties requires …

Development of a lipid profiling system using reverse-phase liquid chromatography coupled to high-resolution mass spectrometry with rapid polarity switching and an …

T Yamada, T Uchikata, S Sakamoto, Y Yokoi… - … of chromatography A, 2013 - Elsevier
Lipidomics requires accurate lipid profiling, which until recently has been challenging at
best. In the present study, we developed a practical workflow for high-throughput and …

A reversed-phase capillary ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling

X Gao, Q Zhang, D Meng, G Isaac, R Zhao… - Analytical and …, 2012 - Springer
Lipidomics is a critical part of metabolomics and aims to study all the lipids within a living
system. We present here the development and evaluation of a sensitive capillary UPLC-MS …

Recent advances in analytical strategies for mass spectrometry-based lipidomics

T Xu, C Hu, Q Xuan, G Xu - Analytica chimica acta, 2020 - Elsevier
Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

Development of a high coverage pseudotargeted lipidomics method based on ultra-high performance liquid chromatography–mass spectrometry

Q Xuan, C Hu, DI Yu, L Wang, Y Zhou, X Zhao… - Analytical …, 2018 - ACS Publications
Lipid coverage is crucial in comprehensive lipidomics studies challenged by high diversity in
lipid structures and wide dynamic range in lipid levels. Current state-of-the-art lipidomics …

Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry

T Cajka, O Fiehn - TrAC Trends in Analytical Chemistry, 2014 - Elsevier
Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

A novel lipidomics workflow for improved human plasma identification and quantification using RPLC-MSn methods and isotope dilution strategies

E Rampler, A Criscuolo, M Zeller, Y El Abiead… - Analytical …, 2018 - ACS Publications
Lipid identification and quantification are essential objectives in comprehensive lipidomics
studies challenged by the high number of lipids, their chemical diversity, and their dynamic …

Chemical derivatization strategy for mass spectrometry‐based lipidomics

F Xia, JB Wan - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Lipids, serving as the structural components of cellular membranes, energy storage, and
signaling molecules, play the essential and multiple roles in biological functions of …