The kidney is a vital organ that demands an extraordinary amount of energy to actively
maintain the body's metabolism, plasma hemodynamics, electrolytes and water …

Mitochondria are heterogeneous and highly dynamic organelles, playing critical roles in
adenosine triphosphate (ATP) synthesis, metabolic modulation, reactive oxygen species …

Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

Chronic kidney disease (CKD) is associated with a variety of distinct disease processes that
permanently change the function and structure of the kidney across months or years. CKD is …

Recent advances have led to a greater appreciation of how mitochondrial dysfunction
contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

In healthy kidneys, interstitial fibroblasts are responsible for the maintenance of renal
architecture. Progressive interstitial fibrosis is thought to be a common pathway for chronic …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …

Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …